Analisis Polimorfisme Gen dan Aplikasinya Dalam Klinik

Gene polymorphism refers to a variation in DNA sequence that occurs population with frequency of 1% or higher. Polymorphism may be single nucleotide (SNP) some repetitive sequences (length polymorphism). Several methods can used analyze polymorphism, included Polymerase Chain Reaction (PCR), sequencing from the conventional method more sophisticated such as Next Generation Sequencing (NGS), fluorescence situ hybridization, comparative genomic and microarrays. Recently, studies have been carried out find relationship between disease severity prognosis, response various drugs, susceptibility environtmental factors toxins, infections cancers.Key words: DNA; gene polymorphism; PCR; clinic.